MECHANISM OF CHEMICAL MUTAGENESIS

Chemical mutagenesis.

Mechanism of proflavin mutagenesis.

The mutagenic action of proflavin on bacteriophage T4 is greater in the presence of defective T4 ligase than in the presence of normal T4 ligase. This suggests that the persistence of single-strand breaks in DNA enhances proflavin mutagenesis.

Chemical mutagenesis: From plants to human

Following the discovery that chemicals, like ionizing radiation, can induce mutations in Drosophila in the 1940s, work on chemical mutagenesis was started in many parts of the world. At the Botany Division of Indian Agricultural Research Institute, chemical mutagenesis studies in crop plants were initiated by M. S. Swaminathan in the 1950s. This brief review deals with progress of chemical muta...

Breeding of New Strains of Mushroom by Basidiospore Chemical Mutagenesis

Chemical mutagenesis of basidiospores of Hypsizygus marmoreus generated new mushroom strains. The basidospores were treated with methanesulfonate methylester, an alkylating agent, to yield 400 mutant monokaryotic mycelia. Twenty fast-growing mycelia were selected and mated each other by hyphal fusion. Fifty out of the 190 matings were successful (mating rate of 26.3%), judged by the formation o...

EMIC: A centralized source of chemical mutagenesis information

In 1969, a group of scientists concerned with the health hazards posed by environmental mutagens formed the Environmental Mutagen Society to encourage interest in and the study of mutagens in the human environment. In order to deal effectively with this potential health problem, these scientists saw the need for a centralized source of published information on chemicals tested for mutagenicity ...